Rejuran Healer Salmon DNA Skin Booster Near Incheon Airport Korea

Polynucleotides: The Molecular Basis of Skin Regeneration

Polynucleotides (PN) are long-chain polymers of nucleotides extracted from salmon (Oncorhynchus keta) sperm DNA through a proprietary purification process. The resulting PN chains have a molecular weight range of 50-1,500 kDa, optimized for biological activity and safety. When injected into the dermis, these PN chains bind to adenosine A2A and A2B purinergic receptors on fibroblast cell surfaces. This receptor binding activates intracellular signaling cascades (primarily the PI3K/Akt and MAPK/ERK pathways) that upregulate gene expression for Type I and Type III collagen, elastin, fibronectin, and glycosaminoglycans. The net result is a comprehensive regeneration of the dermal extracellular matrix -- the structural scaffold that determines skin thickness, elasticity, and hydration.

PDRN vs. PN: Understanding the Terminology

PDRN (polydeoxyribonucleotide) and PN (polynucleotide) are related but distinct molecules. PDRN is a shorter-chain nucleotide polymer (50-1,500 kDa) that acts primarily through A2A purinergic receptor activation. PN includes both PDRN and longer-chain polynucleotides that may have additional biological activities including direct cell membrane stabilization and anti-inflammatory effects. Rejuran Healer contains PN (which includes PDRN), providing the full spectrum of polynucleotide-mediated biological effects. Kim et al. (2019) published in the Journal of Cosmetic Dermatology that PN injection into human skin biopsies resulted in a 28% increase in dermal collagen density and a 35% increase in elastin fiber density at 12 weeks.

Clinical Evidence: Dermal Thickness and Elasticity

Cavallini et al. (2013) conducted a prospective study published in the Journal of Cosmetic and Laser Therapy demonstrating that 3 sessions of intradermal PN injection at 2-week intervals produced a statistically significant increase in skin thickness (measured by high-frequency ultrasound), improved elasticity (measured by elasticity assessment), and enhanced hydration (measured by hydration assessment) that persisted for at least 6 months post-treatment. Gout et al. (2020) in the Aesthetic Surgery Journal reported that PN treatment produced sustained improvement in periorbital fine lines and skin quality for 9 months post-treatment in a cohort of 40 patients, with 87.5% reporting high satisfaction.

Wound Healing and Anti-Inflammatory Properties

Beyond cosmetic skin rejuvenation, polynucleotides have well-documented wound healing and anti-inflammatory properties. Squadrito et al. (2017) in the Journal of Dermatological Treatment showed that PDRN promotes angiogenesis (new blood vessel formation) through VEGF pathway activation, accelerating tissue repair. Galeano et al. (2008) in the Annals of Surgery demonstrated that PDRN significantly accelerated wound healing in a diabetic animal model. These tissue-repair properties are what make Rejuran particularly effective for damaged, photo-aged, and post-procedural skin -- the polynucleotides not only stimulate new collagen but also enhance the overall healing and regenerative environment of the dermis.

References: Kim JH et al. J Cosmet Dermatol. 2019;18(4):1127-1133 (doi:10.1111/jocd.12808) | Cavallini M et al. J Cosmet Laser Ther. 2013;15(6):305-309 () | Gout U et al. Aesthet Surg J. 2020;40(5):NP261-NP268 (doi:10.1093/asj/sjaa041) | Squadrito F et al. J Dermatolog Treat. 2017;28(2):137-142 () | Galeano M et al. Ann Surg. 2008;247(4):680-689 ()