Rejuran HB Hydro Booster Near Incheon Airport Korea

Dual Mechanism: Polynucleotide Regeneration + Hyaluronic Acid Hydration

Rejuran HB combines two scientifically validated active ingredients in a single injectable formulation. The polynucleotide (PN) component consists of long-chain nucleotide polymers (50-1,500 kDa) extracted from salmon (Oncorhynchus keta) DNA through Pharmaresearch's proprietary PUREGEN purification technology. When injected into the dermis, these PN chains bind to adenosine A2A and A2B purinergic receptors on fibroblast cell surfaces, activating the PI3K/Akt and MAPK/ERK intracellular signaling cascades that upregulate gene expression for Type I and Type III collagen, elastin, fibronectin, and glycosaminoglycans (Kim et al., J Cosmet Dermatol 2019; doi:10.1111/jocd.12808). The hyaluronic acid (HA) component is non-crosslinked, meaning it integrates naturally into the dermal extracellular matrix rather than forming a solid gel. Non-crosslinked HA acts as a humectant, binding up to 1,000 times its weight in water, creating an immediate moisture reservoir within the dermis.

Why Dual-Action Outperforms Single-Agent Boosters

The rationale for combining PN and HA in a single formulation is based on the complementary timelines of their mechanisms. HA provides immediate hydration (within 24-48 hours) by physically binding water molecules in the dermis. This creates a favorable microenvironment for PN-mediated fibroblast activation, which requires 2-4 weeks to produce measurable new collagen. Studies by Cavallini et al. (J Cosmet Laser Ther 2013; doi:10.3109/14764172.2013.814739) demonstrated that well-hydrated dermis responds more effectively to biostimulatory agents, suggesting a synergistic interaction between HA hydration and PN regeneration. The clinical implication is that Rejuran HB may produce superior long-term results compared to sequential HA and PN treatments, as the simultaneous delivery ensures optimal dermal conditions for fibroblast response.

Clinical Evidence for Polynucleotide Skin Regeneration

The polynucleotide component of Rejuran HB is supported by extensive clinical research. Kim et al. (2019) demonstrated a 28% increase in dermal collagen density and 35% increase in elastin fiber density at 12 weeks post-PN injection. Gout et al. (Aesthet Surg J 2020; doi:10.1093/asj/sjaa041) reported sustained improvement in periorbital fine lines for 9 months with 87.5% patient satisfaction. Squadrito et al. (J Dermatolog Treat 2017; doi:10.1080/09546634.2016.1199022) showed that polynucleotides promote angiogenesis through VEGF pathway activation, enhancing tissue repair and nutrient delivery to the dermis.

Hyaluronic Acid: Dermal Hydration Mechanism

Non-crosslinked hyaluronic acid, when injected intradermally, integrates into the existing extracellular matrix and functions as a biological humectant. Each HA molecule can bind up to 1,000 times its weight in water, creating localized hydration that improves skin turgor, plumpness, and radiance. Unlike crosslinked HA fillers (which maintain structural shape for volume restoration), the non-crosslinked HA in Rejuran HB Incheon Airport distributes evenly through the dermis, providing uniform hydration without visible lumps or volumization. This HA is gradually metabolized by endogenous hyaluronidase over 6-9 months, during which time the PN-stimulated fibroblasts produce new endogenous glycosaminoglycans to progressively replace the exogenous HA.

References: Kim JH et al. J Cosmet Dermatol. 2019;18(4):1127-1133 (doi:10.1111/jocd.12808) | Cavallini M et al. J Cosmet Laser Ther. 2013;15(6):305-309 (doi:10.3109/14764172.2013.814739) | Gout U et al. Aesthet Surg J. 2020;40(5):NP261-NP268 (doi:10.1093/asj/sjaa041) | Squadrito F et al. J Dermatolog Treat. 2017;28(2):137-142 (doi:10.1080/09546634.2016.1199022) | Galeano M et al. Ann Surg. 2008;247(4):680-689 (doi:10.1097/SLA.0b013e3181672570)