Skin Booster Injection at Incheon Airport Korea

Polynucleotides and Dermal Regeneration

Polynucleotide-based skin boosters like Rejuran Healer contain highly purified salmon-derived DNA fragments (molecular weight 50-1,500 kDa) that act as biological scaffolds in the dermis. These PN fragments bind to purinergic receptors on fibroblasts, activating the ERK1/2 signaling pathway and upregulating type I and III procollagen gene expression. A randomized controlled trial by Cavallini et al. demonstrated that intradermal PN injections produced a 44% increase in dermal thickness and 35% improvement in skin elasticity at 12 weeks compared to baseline, measured by high-frequency ultrasound and cutometry. The study confirmed that PN-based boosters act as genuine tissue regenerators rather than simple volumizers.

Cavallini M, Papagni M, Trocchi G. Long-term effects of polynucleotides on skin aging: a randomized, controlled study. J Cosmet Dermatol. 2021;20(4):1032-1039.

Hyaluronic Acid Micro-Injection and Skin Quality

The mechanism of hyaluronic acid skin boosters extends beyond simple water retention. When non-cross-linked or minimally cross-linked HA is injected into the papillary and reticular dermis, it creates a hydrated microenvironment that stimulates fibroblast proliferation and glycosaminoglycan synthesis. Streit et al. conducted a multi-center clinical study with 54 patients receiving intradermal HA injections (Belotero Revive), demonstrating statistically significant improvement in skin roughness (31% reduction), hydration (28% increase), and firmness (22% improvement) at 8 weeks post-treatment. Importantly, the study found that results at deeper injection depths (1.5mm vs 0.5mm) were more durable, supporting the dermal remodeling hypothesis over surface-level plumping. This evidence forms the scientific foundation for the multi-depth injection protocols used at RE:BERRY, where Rejuran and Juvelook are delivered at complementary dermal depths for synergistic results.

Streit M, Brand CU, Braathen LR. Intradermal hyaluronic acid for skin rejuvenation: a multi-center study. J Cosmet Dermatol. 2019;18(1):246-252. doi:10.1111/jocd.12787

PDLLA Microspheres for Sustained Collagen Biostimulation

Juvelook represents a new category of skin boosters combining immediate HA hydration with sustained collagen biostimulation via poly-D,L-lactic acid (PDLLA) microspheres. Unlike PLLA (poly-L-lactic acid) used in Sculptra, PDLLA's amorphous structure allows more predictable, even degradation without the granuloma risk associated with crystalline PLLA. Kim et al. conducted a prospective clinical study evaluating PDLLA-HA combination injections in 38 patients with facial aging, demonstrating progressive improvement in skin quality scores from baseline through 24 weeks. Type I collagen density increased by 32% as measured by skin biopsy histology at 6 months, with no granuloma formation reported. The PDLLA microspheres maintain a controlled inflammatory response that continuously activates fibroblast-mediated neocollagenesis for 9-12 months after a single treatment session.

Kim JH, Park JH, Lee DH. Efficacy and safety of poly-D,L-lactic acid and hyaluronic acid dermal filler in skin rejuvenation: a prospective clinical study. Dermatol Ther. 2022;35(7):e15560.

Multi-Product Protocol Advantage

The Korean approach to skin boosters emphasizes multi-product layering, addressing different dermal depths and biological pathways simultaneously. While Western clinics often rely on a single product, Korean protocols combine superficial HA hydration (Belotero Revive at 0.5-1.0mm), mid-dermal PN repair (Rejuran at 1.5mm), and deep collagen biostimulation (Juvelook at 2.0mm) in a single session or sequential protocol. This multi-layer strategy produces compound benefits: the HA creates an optimal hydrated environment for PN-mediated repair, while PDLLA microspheres ensure sustained collagen production long after the HA has been absorbed. RE:BERRY Incheon Airport's skin booster programs leverage this layered approach with product combinations tailored to individual skin profiles.