Fat Freezing & Body Contouring Near Incheon Airport Korea

Cryolipolysis: The Science of Fat Freezing

Cryolipolysis exploits the differential sensitivity of adipocytes to cold temperatures compared to surrounding tissues. Fat cells undergo apoptosis (controlled cell death) when exposed to temperatures between -11°C and +5°C, while skin, nerves, and muscle remain unaffected. This selective vulnerability occurs because adipocytes contain high concentrations of saturated fatty acids that crystallize at these temperatures, triggering an inflammatory cascade that leads to gradual fat cell elimination over 2-12 weeks. The destroyed adipocytes are phagocytosed by macrophages and processed through the hepatic system without clinically significant changes in serum lipid levels. This mechanism was first described by Manstein et al. in 2008 and has been validated in over 100 peer-reviewed studies.

Onda Coolwaves: Microwave-Selective Fat Destruction

Onda’s patented Coolwaves technology uses 2.45GHz microwave energy specifically calibrated to the resonant frequency of water molecules in fat tissue. Unlike radiofrequency, which heats indiscriminately through impedance, microwave energy at this frequency is preferentially absorbed by the high water content within and between adipocytes. A multicenter clinical study by Bacci et al. (2019, n=58) demonstrated average circumference reduction of 3.6cm after a single Onda body contouring session, with simultaneous collagen contraction providing a skin-tightening effect that prevents post-treatment laxity. The integrated cooling system (Coolwaves) maintains surface temperature below 42°C while deep fat reaches the therapeutic temperature of 55-60°C, ensuring patient comfort and safety.

Injectable Lipolysis: Deoxycholic Acid Mechanism

Deoxycholic acid (the active ingredient in Very Slim injections) is a naturally occurring bile salt that disrupts adipocyte cell membranes through detergent-like action. When injected into subcutaneous fat, it causes rapid adipocytolysis — the physical destruction of fat cell walls — followed by an inflammatory response that clears the cellular debris over 4-6 weeks. The FDA approved synthetic deoxycholic acid (Kybella/ATX-101) for submental fat reduction based on pivotal trials showing 68.4% of patients achieving clinically meaningful improvement (n=506 pooled). At RE:BERRY, deoxycholic acid injections are used for small, targeted fat deposits where energy-based devices are less practical, such as double chin, jowl fat, and bra line bulge.

Combination Protocols: Synergistic Fat Reduction

Emerging evidence supports combining multiple fat reduction modalities for enhanced outcomes. A comparative study by Friedmann et al. (2020, n=42) demonstrated that combining energy-based fat destruction with injectable lipolysis achieved 40% greater circumference reduction compared to single-modality treatment. The rationale is that energy-based devices (Onda, cryolipolysis) optimally target deeper subcutaneous fat, while injectable agents address superficial subdermal fat deposits. Furthermore, adding skin-tightening treatments like REVINAS addresses the potential for skin laxity following significant fat volume loss. This multi-layer approach forms the basis of RE:BERRY’s comprehensive body contouring philosophy.

Manstein D et al. Lasers Surg Med. 2008;40(9):595-604. doi:10.1002/lsm.20670

Bacci PA et al. Aesthetic Plast Surg. 2019;43(4):1061-1068. doi:10.1007/s00266-019-01373-1

Friedmann DP et al. Dermatol Surg. 2020;46(11):1476-1482. doi:10.1097/DSS.0000000000002365